5. Insulin Resistance: The Root of Many Evils
This brings us to what is arguably the most common root cause driving both inflammation and cholesterol problems in people who look healthy on the outside: insulin resistance. In simple terms, insulin resistance is when your body’s cells have trouble responding to the hormone insulin, which makes it difficult to handle sugar from your diet. It shows up as high triglycerides, high blood pressure, fatty liver disease, pre-diabetes, and eventually, type 2 diabetes.
Insulin resistance is an independent risk factor for heart disease, and it may be an even bigger driver than cholesterol. The Quebec Cardiovascular Study found that people with high insulin levels—the hallmark of insulin resistance—had more than five times the risk of heart disease, a much bigger risk than having high LDL. The scariest part is how easily it’s missed. You can have significant insulin resistance while your fasting blood sugar and A1C look completely normal. Your doctor sees those numbers and says you’re fine, but they don’t show how much extra insulin your pancreas is pumping out to keep those numbers in range. If your blood sugar is normal only because your pancreas is working three times harder than it should be, that isn’t health. It’s compensation, and it comes at a cost.
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