The 5 best supplements to soothe nerve pain and tingling

3. Acetyl-L-Carnitine (ALCAR)
The third best supplement for peripheral neuropathy is acetyl-L-carnitine, also known as ALCAR. This is an amino acid and a powerful antioxidant that plays a critical role in your body’s energy production. Specifically, it’s vital for fatty acid metabolism within your mitochondria—the powerhouses of your cells. For your nerves, ALCAR is important in controlling nerve growth factors and the neurotransmitters that your nervous system uses to communicate.

What makes ALCAR so compelling is the strength of the research behind it. Many studies, including randomized, double-blind, placebo-controlled clinical trials (the gold standard of medical research), have shown that ALCAR effectively alleviates nerve pain. It has also been shown to increase vibration perception in patients with neuropathy, particularly diabetic neuropathy, which is a sign of improved nerve function. If you’re looking for a supplement with solid scientific backing for nerve pain, ALCAR is one of the top contenders. Typical dosages used in studies are between 2 to 3 grams daily. As with the others, please consult your physician before adding it to your regimen.

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